PolyOrg, Inc.

Peptide Nucleic Acid Monomers

Peptide Nucleic Acids are analogs of DNA in which the phosphate backbone is replaced with a peptide like backbone. Due to their unique structure; PNA molecules have possible applications as antisense therapeutics, diagnostic markers, or molecular biology products.

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Oligonucleotide Reagents arrow PolyOrg Sulfa (POS)



PolyOrg Sulfa (POS)

3-Phenyl-1,2,4-Dithiazoline-5-one

Cat. Number: 16-1517
Cas. Number:
MF: C8H5NOS2
FW: 195.27


  • Soluble and stable in anhydrous acetonirile
  • Mixed bases 25-mer of DNA phosphorothioates gave less than 1% P=O using 60 second sulfurizing time
  • Smell less crystalline powder with formula weight 195.27

3-phenyl 1,2,4-dithiazoline-5-one* (POS) is a novel sulfurizing reagent, highly soluble and stable in anhydrous acetonitrile. POS is a yellow crystalline product with no foul smell.

0.1M solution of POS in anhydrous acetonitrile is recommended for the synthesis of DNA phosphorothioates using contact time 60 second.

U.S. Patent #: 6,500,944



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