Soluble and stable in anhydrous acetonitrile
Mixed bases 25-mer of DNA phosphorothioates gave less than 1% P=O using 60 second sulfurizing time
Smell less crystalline powder with formula weight 195.27
3-phenyl 1,2,4-dithiazoline-5-one* (POS) is a novel sulfurizing reagent, highly soluble and stable in anhydrous acetonitrile.
POS is a yellow crystalline product with no foul smell. 0.15M solution of POS in anhydrous acetonitrile is recommended for the synthesis of DNA phosphorothioates using contact time 60 second.
U.S. Patent #: 6,500,944
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